Monoclonal antibodies, a powerful agent against SARS-CoV 2 infection

The Preventive Medicine and Public Health specialty has among its main functions epidemiological surveillance, infection prevention and control, and health promotion. Under this premise, the Jiménez Díaz Foundation recently hosted the 1st conference “The role of preventive medicine services in immunization” in order to …


The Preventive Medicine and Public Health specialty has among its main functions epidemiological surveillance, infection prevention and control, and health promotion. Under this premise, the Jiménez Díaz Foundation recently hosted the 1st conference “The Role of Preventive Medicine Services in Immunization” in order to assess the level of knowledge and implementation of the use of monoclonal antibodies (AbMo) against Covid-19 by these departments, but also with the aim of promoting the forum to think about the role of preventive medicine services in prevention in patients with weakened immunity.

As explained by Dr. Maria Dolores Martin Rios, Head of the preventive medicine service of the four Quirónsalud hospitals integrated into the public network of Madrid –the University Hospitals Rey Juan Carlos (Móstoles), Infanta Elena (Valdemoro) and General de Villalba (Collado Villalba), in addition to the Fundación Jiménez Díaz itself – among the various functions of the service, one of great importance is that carried out in the Immunization Unit, which “serves people with special needs for vaccinations and the health of travelers“, with a comprehensive and personalized approach, for which he believes that recommendations for prophylaxis in high-risk patients correspond to doctors of this specialty. Namely, the conference talked about the importance of Preventive Medicine Services, as well as reference organizations such as the Vaccine Network of the Spanish Society for Preventive Medicine, Public Health and Health Management, to lead this goal.

Prevention methods

Thanks to important research work and clinical trials conducted in the last year, immunization-based preventive strategies aimed at protecting the most vulnerable population after SARS-CoV infection have increased significantly.


In that sense, dr. Helena MozaHead of the Immunization Unit of the Service for Preventive Medicine of the aforementioned network of hospitals, outlines three preventive methods currently available: vaccines for use in the primary series and boosters, which offer protection against serious disease; vaccines adapted to new variants, to strengthen the immune response and therefore protect against all clinical manifestations; and passive immunization through the use of prophylactic drugs for high-risk individuals who do not respond to vaccination and who “some hospitals in different autonomous communities have already accepted it as a new service in their consultations“.

mAb as preventive therapy against SARS-CoV 2

During the conference, the importance of monoclonal antibodies was highlighted, which represent a very powerful tool, present and future, as an effective method of passive immunization against infectious diseases, and especially against the infection of Covid-19.

Furthermore, as Dr. Moza points out, “we have approval for the use of Evusheld (AZD7442), a combination of two long-acting IgG1k monoclonal antibodies – cilgavimab and tixagevimab – derived from B cells of convalescent patients with SARS-CoV-2 infection“. The joint application of these two antibodies is included in the Spanish vaccination strategy against Covid-19, as a complement to vaccination in persons with a high degree of immunosuppression.

On its part, dr. Martín Ríos assures that one of the commitments reached that day was “the formation of working groups and education strategies to continue working on the implementation of this type of therapy, as well as on other aspects related to the immunization of our services“, and adds that it is a workshop “It was a starting point for new meetings, which gives us great pleasure“.

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